Jacqueline Freire Machi, Ph.D.

Biography

Jacqueline Freire Machi received her Ph.D. in cardiovascular physiology from University of Sao Paulo, Brazil. Her doctoral work focused on understanding the mechanisms by which metabolic disease triggers cardiovascular dysfunction for the development of therapeutic strategies including exercise. Throughout her career, with approximately 15 years of research experience she developed a solid background in metabolism, autonomics, exercise training and cardiovascular physiology in the context of metabolic syndrome, aging and toxic chemical exposure. During her pre- and postdoctoral studies, she received training on the use of echocardiography for assessment of cardiac function, analysis of autonomic activity of blood pressure and metabolism.

In 2021, Dr. Machi joined Florida Atlantic University Charles E. Schmidt College of Medicine as an Assistant Professor in the department of Biomedical Science. Her short-term research goal is to understand the role of endothelial c-Myc preventing obesity and cardiovascular dysfunction. Her long-term research goal, is to develop an independent research program in obesity-associated co-morbidities to better understand the mechanisms associated with these conditions for development of preventative and therapeutic strategies that can be translated to clinic.

Education

• 2007: B.S., Physical Education, São Judas Tadeu University, São Paulo, Brazil.
• 2010: M.S., Exercise Physiology, São Judas Tadeu University, São Paulo, Brazil.
• 2015: Ph.D., Physiology/Cardiovascular, University of Sao Paulo, São Paulo, Brazil.
• 2018: Post-Doctoral., Cardiotoxicity, Nova Southeastern University, Davie, Florida.
• 2021: Post-Doctoral., Vascular Biology, University of Miami, Miami, Florida.

Work History

• 2021-Present: Research Assistant Professor, Department of Biomedical Science, Florida Atlantic University, Boca Raton, FL.
• 2018-2021: Postdoctoral Associate, Department of Molecular and Cellular Pharmacology, University of Miami, Florida, FL.
• 2017-2018: Postdoctoral Research Associate, Department of Neuro Immune Medicine, Nova Southeastern University, Davie, FL.
• 2015-2017: Research Associate, Department of Neuro Immune Medicine, Nova Southeastern University, Davie, FL.
• 2014-2018: Research Scientist, Miami VA Health Care System, Miami, FL, USA.

Scholarly Activity

Research Support

• President's Faculty Research and Development Grant. Role: PI from Nova Southeastern University (2017-2018). Dietary fructose as a risk factor for Gulf War Illness: Exercise Challenge.
• President's Faculty Research and Development Grant. Mariana Morris. Role: Co-investigator from Nova Southeastern University. (2018-2019). A Neurotoxin Model: Effects on cardiovascular, autonomic and oxidative stress profile.

Peer-Reviewed Publications

• Qi Y, Qadir MMF, Hastreiter AA, Fock RA, Machi JF, Morales AA, Wang Y, Meng Z, Rodrigues CO. Endothelial c-Myc knockout enhances diet-induced liver inflammation and fibrosis. FASEB J. 2022 Jan;36(1):e22077. doi: 10.1096/fj.202101086R. PubMed PMID: 34878671.
• Cruz PL, Moraes-Silva IC, Ribeiro AA, Machi JF, de Melo MDT, Dos Santos F, da Silva MB, Strunz CMC, Caldini EG, Irigoyen MC. Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system. BMC Endocr Disord. 2021 Jun 28;21(1):133. doi: 10.1186/s12902-021-00795-6. PubMed PMID: 34182970; PubMed Central PMCID: PMC8240217.
• Stoyell-Conti FF, Irigoyen MC, Sartori M, Ribeiro AA, Dos Santos F, Machi JF, Figueroa DMT, Rodrigues B, De Angelis K. Aerobic Training Is Better Than Resistance Training on Cardiac Function and Autonomic Modulation in Female ob/ob Mice. Front Physiol. 2019;10:1464. doi: 10.3389/fphys.2019.01464. eCollection 2019. PubMed PMID: 31866872; PubMed Central PMCID: PMC6906161.
• da Silva Dias D, Moraes-Silva IC, Bernardes N, de Oliveira Brito-Monzani J, Stoyell-Conti FF, Machi JF, Llesuy S, Irigoyen MC, De Angelis K. Exercise training initiated at old stage of lifespan attenuates aging-and ovariectomy-induced cardiac and renal oxidative stress: Role of baroreflex. Exp Gerontol. 2019 Sep;124:110635. doi: 10.1016/j.exger.2019.110635. Epub 2019 Jun 11. PubMed PMID: 31195102.
• Freire Machi J, Schmidt R, Salgueiro LM, Fernandes Stoyell-Conti F, de Andrade Barboza C, Hernandez DR, Morris M. Exercise benefits the cardiac, autonomic and inflammatory responses to organophosphate toxicity. Toxicol Rep. 2019;6:666-673. doi: 10.1016/j.toxrep.2019.06.015. eCollection 2019. PubMed PMID: 31673494; PubMed Central PMCID: PMC6816132.
• Barboza CA, Fukushima AR, Carrozzi N, Machi JF, Dourado PMM, Mostarda CT, Irigoyen MC, Nathanson L, Morris M, Caperuto EC, Rodrigues B. Cholinergic Stimulation by Pyridostigmine Bromide Before Myocardial Infarction Prevent Cardiac and Autonomic Dysfunction. Sci Rep. 2019 Feb 21;9(1):2481. doi: 10.1038/s41598-019-38841-y. PubMed PMID: 30792425; PubMed Central PMCID: PMC6385301.
• Stoyell-Conti FF, Santos F, Machi JF, Hernandez DR, Barboza CA, Irigoyen MC, De Angelis K, Morris M. Measurement of Mouse Heart Rate Variability using Echocardiographic System. J Cardiovasc Echogr. 2018 Apr-Jun;28(2):90-94. doi: 10.4103/jcecho.jcecho_51_17. PubMed PMID: 29911004; PubMed Central PMCID: PMC5989555.
• Sartori M, Conti FF, Dias DDS, Dos Santos F, Machi JF, Palomino Z, Casarini DE, Rodrigues B, De Angelis K, Irigoyen MC. Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice. Front Physiol. 2017;8:572. doi: 10.3389/fphys.2017.00572. eCollection 2017. PubMed PMID: 28878683; PubMed Central PMCID: PMC5572327.
• Machi JF, Dias Dda S, Freitas SC, de Moraes OA, da Silva MB, Cruz PL, Mostarda C, Salemi VM, Morris M, De Angelis K, Irigoyen MC. Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress. Clin Interv Aging. 2016;11:341-50. doi: 10.2147/CIA.S88441. eCollection 2016. PubMed PMID: 27042032; PubMed Central PMCID: PMC4809309.
• Machi JF, Bernardes N, Mostarda C, Moraes-Silva IC, Irigoyen MC, De Angelis K, Wichi RB. Walking promotes metabolic and baroreflex sensitivity improvement in fructose-fed male rats. Eur J Appl Physiol. 2013 Jan;113(1):41-9. doi: 10.1007/s00421-012-2411-z. Epub 2012 May 8. PubMed PMID: 22565302.

Honors

• Postdoctoral Minority Fellowship Award. Jacqueline Machi, PhD, Angiocrine Signals in Metabolic Dysfunction. American Diabetes Association. March 2020 (This award was canceled due to the COVID-19 financial crisis).
• Platform presentation at the American Heart Association Scientific Sessions 2019, Session Title: Novel insights into coronary arterial disease and aging. Philadelphia, PA. Loss of Endothelial c-Myc triggers visceral fat accumulation in aging mice associated with serum increase in cholesterol and leptin
• Travel Award - Arteriosclerosis, thrombosis, and Vascular Biology (ATVB). Grant for Early Career Investigators. Title: Loss of Endothelial c-Myc triggers visceral fat accumulation in aging mice associated with serum increase in cholesterol and leptin. American Heart association, Scientific Sessions in Philadelphia, PA 2019.
• Honorable Mention, Young Investigator Basic Science Presentation. Exercise Training Improves Cardiac Function in Mice Exposed to a Model of Gulf War Illness: Combined use of Corticosterone and Diisopropyl fluorophosphate (DFP). Miami VA Research Day 2016.
• Educational award, European Society of Cardiology (ESC) Grants. This grant aims to encourage and support the development of the professional careers towards the fight against cardiovascular disease. Annual meeting ESC: Italy Rome 2016.
• Master Fellowship – State of Sao Paulo Research Foundation (FAPESP) – (2009-2012). Brazilian National Research Council
• Pre-doctoral Fellowship – Brazilian National Research Council (CAPES) – (2012-2015). Brazilian National Research Council.
• International Scholarship – Brazilian National Research Council (CNPQ) – (2014). Research exchange program between University of Sao Paulo Brazil and Nova Southeastern University, Florida.
• Second place award for best undergraduate project, Physical Education bachelor's degree. Comparison of cardiovascular responses to exercise training between males and females, São Judas Tadeu University.